Over recent years, drug release/dissolution from solid pharmaceutical dosage forms has been the subject of intense and profitable scientific developments. Whenever a new solid dosage form is developed or produced, it is necessary to ensure that drug dissolution occurs in an appropriate manner. In the present study sustained release floating microsphere of diltiazem hydrochloride were prepared by using non aqueous solvent evaporation method using polycarbonate, chitosan, ethyl cellulose, HPMC and acrycoat as materials in various quantities, in varying ratio to formulate 20 formulations of the floating microsphere. The drug release was studied using a USP 24 dissolution apparatus type I (Veego Scientific, Mumbai) at 100 rpm in 0.1N hydrochloric acid as dissolution medium (900 ml) maintained at 37±1°C. It has been noticed that on increasing the concentration of polymer it decreased the drug release from microspheres. The high concentration of polymer makes the microsphere stiff. This hardness of microsphere decreases the rate of drug release from microspheres. The F3 released 98.72% drug at 16 hrs. The F3 exhibited the sustained release of drug from microspheres. The release mechanism was explored and explained with zero order, first order, higuchi and korsmeyer and peppas equations.
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